endocrine disorders, such as hypothyroidism and hyperthyroidism.electrolyte disorders, especially those affecting potassium and calcium.infections, in particular bacterial and viral infections that cause blood infections.dietary supplements or weight-loss supplements, especially those containing ephedra and creatine.hereditary muscle disorders known as metabolic myopathies.extensive burns that cause muscle damage.heatstroke or overexertion in extreme environments.not being able to move for a prolonged period of time.crushing damage to skeletal muscle tissues.There are many causes and risk factors for rhabdomyolysis that are currently recognized. inherited, caused by genetic conditions such as muscular myopathies.the result of external injury, infection, or substances.Currently, cases of rhabdomyolysis are classified as one of the following: Researchers are still exploring the full range of factors that may influence the risk of rhabdomyolysis. Many cases not caused by direct trauma are considered to be the result of several different factors. But generally, anything that causes muscle injury, dehydration, or kidney injury increases a person’s chances of developing the condition. Most cases of rhabdomyolysis are considered a part of crush syndrome, a condition that occurs as the result of traumatic skeletal muscle injury. Severe cases often cause severe muscle pain, however, and can be life-threatening. Minor cases may not cause any noticeable symptoms and might only be spotted with blood serum tests. The complications associated with rhabdomyolysis depend on the severity of the case and on several individual factors. This can cause dehydration as well as reduce the flow of blood to the kidney, thereby increasing the risk of organ damage. Other cellular enzymes, especially creatine kinase (CK), also put stress on the kidney.ĭamaged muscle tissues also retain body fluids. If blockages become severe enough, kidney damage and failure can occur. Myoglobin can block the complex tubing system of the kidney. Several of these components can lead to kidney damage, with the most common being the protein pigment myoglobin. These components are then released into the bloodstream to be filtered and removed from the body. When skeletal muscle tissues are damaged or die, their components are broken down. Share on Pinterest The skeletal muscle tissue deteriorates in those with rhabdomyolysis.
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